الفهرس 
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Abstract
Stroke is considered as a global epidemic and a major public health-care concern; it is usually associated with a detrimental impact on survival and quality of life of the patient, and a high economic cost. Worldwide,stroke is the second most common cause of mortality and the most common cause of disability (WHO, 2015). While the incidence of stroke is decreasing in high-income countries, the incidence is increasing in low-income countries(Shrivastava et al., 2013).Official national statistics indicate that diseases of the circulatory system, including stroke, are the primary cause of death in Egypt and account for one third of all deaths. Stroke accounts for 6.4% of all deaths and thus ranks 3rd after heart disease and gastrointestinal (especially liver) diseases. Deaths attributable to stroke have remained relatively unchanged during the past10 years (Abd-Allah and Moustafa,2014 Diagnosis of acute ischemic stroke is difficult because Computed tomography CT results may appear normal in the early stage and Magnetic resonance imaging MRI is not always possible in golden time of treatment.Thus, many cases experience delays in receiving intravenous thrombolysis treatment and therefore poor clinical outcome and prognosis.The use of specific biomarkers might aid stroke diagnosis and might permit rapid referral of patients to stroke centers and early management