الفهرس 
A Pharmaceutical Study on Raft Forming Systems of Gabapentin
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Abstract
The main aim of this work is to develop floating gastroretentive dosage form of gabapentin. Gabapentin, being a freely water-soluble drug, is considered a challenging candidate to be formulated as sustained release dosage form. GBP was formulated as floating dosage form. This helps in maintaining GBP at its site of absorption for a prolonged period of time, thus reduce frequency of dosing, increase patient compliance and increase bioavailability. The work in this thesis is divided into: Chapter I:Gastroretentive raft liquid delivery system as a new approach to release extension for Gabapentin as a model of a carrier-mediated drug. Chapter II:Preferential wax extraction as a gastroretentive technique for enhancing the bioavailability of Gabapentin as a model of a narrow therapeutic window drug. Chapter III: In-vivo performance of Gabapentin from the optimized floating raft forming system and optimized floating porous beads.It was concluded that floating raft forming system has been achieved which could be suitable for special populations as geriatrics and pediatrics who find difficulty in swallowing controlled release solid dosage forms of GBP thus leading to improved efficacy due to enhanced patient compliance. GBP was formulated as floating porous beads using preferential wax extraction technique through solvent diffusion method. The achieved optimized floating porous beads could be suggested as a selected candidate for continuous delivery of GBP in the stomach with controlled release profile over prolonged period of time