الفهرس 
Matrix metalloproteinases expression in pediatric brain tumors and relation to MicroRNAs
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Abstract
Gliomas are considered the most widespread malignancy of the brain. Which are known for its aggressive form. MMPs are known for their role in degrading the extracellular matrix between cancer cells, which associates with tumor metastasis. Expression of 82 miRNAs and family members of MMPs were evaluated in 40 pediatric brain malignancies from formalin fixed paraffin embedded (FFPE) tissues, using quantitative real time PCR (qRT-PCR). Twenty-one microRNAs are significantly differentially expressed between gliomas groups. 13 microRNAs miR-21, miR-30b, miR-423, miR-486 , miR-527, miR-19a, miR-19b, miR-192, miR-24, miR-27a, miR-361, miR-584 and miR-340 that were significantly deregulated (P < 0.05) in HGG decline compared to LGG , 8 microRNAs miR-10a, miR-196b, miR-26a, miR-34a, miR-885, miR-92b, miR-149 and miR-7-1 were upregulated in HGG. In order to identify potential genetic markers, MMPs were measured between gliomas group. MMP-2 and MMP-9 showed to be upregulated in HGG with {u2265}1 FC. MMP-2 expression was significantly upregulated in the non-responders compared to responders. Finally miR-92b showed to be overexpressed higher in HGG which might play a role in poor prognosis in patient’s survival