الفهرس 
Immunohistochemical expression of Toll- Like- Receptor-2 in oral epithelial dysplasia induced in experimental rats and its possible relation to mast cell count :An animal study
CONTENTSOnly 14 pages are availabe for public view
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Abstract
TLR-2 is a protein that is present in many cells, but its activation occurs due to microbial infection or genetic mutation. TLR-2 was significantly associated with the aggressive behavior of OSCC. Although the phenotypes of TLR-2 in different types of solid tumors have been extensively characterized, the expression and functional properties of TLR-2 in premalignant lesions remain to be determined. The infiltration of MCs has been shown to be an early and predictable characteristic of many pre-neoplastic cells, and may represent one of the earliest indications that a cell population has become committed to malignancy. This study was conducted to evaluated the expression of TLR-2 in OED and correlate it with MCC. A total of 48 adult male albino rats with an age range of 3 to 4 months and with a weight range of 100 to 200 gm were selected. The rats were randomly distributed into two groups: control and experimental groups. Each group was further subdivided into two subgroups according to the time of sacrifice (after 6 and 9 weeks from the start of painting). Six rats were housed under the same conditions and did not receive any treatment. Forty two rats were anesthetized by ketamine 80-100 mg/kg intraperitonealy and xylazine 10-12.5 mg/kg (IP). The buccal mucosa was painted with a number 3 camel hairbrush. The rats had their buccal mucosa painted (topically) with DMBA and formaldehyde, 0.5% DMBA in acetone 3 days/week, and after 9 days 10% formaldehyde/water was used side by side with DMBA throughout the study period (6 and 9 weeks). Euthanasia of rats was done at 6 weeks (group A1and B1) and 9 weeks (group A2 and B2) interval from the start of painting