الفهرس 
IntroductionOnly 14 pages are availabe for public view
 |  | from | 97 |  |  |
| | | from | 97 | | |
Abstract
Hyperemesis gravidarumis a severe form of nausea and vomiting thatdefined as the occurrence of more than three episodes of vomiting per day with ketonuria and 5% weight loss.
The etiology of hyperemesis gravidarum is still unknown. Many possible etiological factors are suggested such asHelicobacter pylori (H. pylori) infection, high levels of hormones as estrogen, progesterone and beta-human chorionic gonadotropin (βhCG), Decreased levels of thyroid stimulating hormone (TSH) and hysteria or conversion disorder.
DHEAis a precursor of estradiol (E2) and Testosterone (T), originates from the adrenal zona reticularis and from ovarian theca cells. It is converted into androstenedione (4-dione) and then into potent androgens and/or estrogens in peripheral tissues hence its possible role in the pathogenesis of hyperemesis gravidarum.
Aim of the study
The aim of this study was toassess and correlate the serum DHEA level in pregnant women complaining of Hyperemesis gravidarum.
Methodology
This Cross-Sectional observational study included 94 pregnant women at 5 – 13 weeks of gestation attending into outpatient clinic of Obstetrics and Gynecology, Suez Canal University Hospital from the interval of 2017 till 2020.
47 females were admitted for hyperemesis gravidarum and considered a study group and another 47 females continue normal 1st trimester and considered as control group.
All included patients were subjected to history taking, vital signs examination, physical examination, examination of mucous membrane condition, skin turgor, neck veins, mental status, thyroid examination, Complete blood count, random blood sugar, urine examination for ketonuria, aspartate transaminase, alanine transaminase, urea, creatinine, thyroid stimulating hormone and serum DHEA level.
Resultsof the current study show:
None statistically significant difference between the two groups according to age, parity and gestational age (p=0,080,0.331, 0.898 respectively).
Statistically significant difference between the two groups according to serum DHEA level (p= <0.001).
Statistically significant difference between the mild and severe cases of HG according to serum DHEA level (p= 0.012).
None statistically significant difference in the study group according to relation between acetone, and complications to DHEA level, (p=0.907, 0.54 respectively).
Statistically significant correlation between the number of vomitus and the DHEA level (p= 0.007).
Statistically significant difference between the non-dehydrated and dehydrated cases of HG according to serum DHEA level (p= 0.018).
At a cut off value >1.03 of DHEA has sensitivity of 82.98% and specificity of 78.72% for diagnosing hyperemesis gravidarum with Positive predictive value76.6% and negative predictive value 82.2% (AUC = 0.935, P = <0.001).