الفهرس 
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Abstract
Background: Onychomycosis (OM) is an infection of the nail plate that is prevalent among the ageing population. Onychomycosis is difficult to treat with low initial cure rates, high rates of relapseand reinfection. Present treatment options include oral and topical therapies with oral therapies yielding better results.Tazarotene is asynthetic retinoid, with immunomodulating properties and anti-inflammatory activity. Tazarotene has antifungal activity specially while its combined with systemic antifungal.
Objectives:This study aims to Compare the effect of topical tazarotene on onychomycosis and systemic antifungal.
Patients and Methods: A comparative study. Thirty onychomycosispatients were selected from the outpatient clinic of Dermatology, STDs and Andrology, Faculty of medicine, Fayoum University.They were divided into 3 groups, group (1) included 10 patients treated by topical Tazarotene, group (2) included 10 patientstreated by systemic antifungals,group(3) included 10 patients treated by both.The three groups were evaluated clinically by onychomycosis severity index (OSI) and alsomycological cultures and potassium hydroxide stains were performed on nail samples taken by scraping or clipping before and after treatment.
Results:There was no statistically significant difference with p-value >0.05 between the three study groups as regards clinical assessments (OSI) and culture findings before treatment and 3 months follow up. There was a high statistically significant improvement of clinical assessment and culture findings with p-value <0.05 in-group 1(Tazarotene), group 2(systemic antifungal), group3(both).
Conclusion:Our findings suggest thatTazarotene is an effective and safe treatment option for mild and moderate cases of onychomycosis.