الفهرس 
S YSTEMIC L UPUS E RYTHEMATOSUSOnly 14 pages are availabe for public view
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Abstract
Late onset Systemic Lupus Erythematosus: Different clinical, serological presentations and damage compared to adult lupus in Egypt
Marwa Mohamed Elsayed Mohamed Hefny, Samah Abd-ElRahman Elbakry, Maryam Ahmad Abdul-Rahman, Fatma Mohammed Badr
Internal Medicine, Rheumatology and Immunology, Faculty of Medicine, Ain Shams University, Cairo
*Corresponding author: Marwa Mohamed Elsayed, Mobile: 01061933737,
Email: merojimmy.mm@gmail.com
ABSTRACT
Background: Comparing cases of adult onset and late onset systemic lupus erythematous (SLE) reveals significant differences in clinical, serological, disease activity, and damage score.
Objective: This study aimed to analyze clinical manifestations, laboratory data, serological markers, and prognosis of late-onset SLE (L-SLE) and for comparing with adult- onset SLE.
Patients and Methods: One hundred fifty individuals with SLE were included in a cross-sectional study conducted at Ain Shams University Hospital divide into group 1: 100 cases with adult-onset (age of onset ≥ 19 years and below 50 years). group 2: 50 Patients with L-SLE (age of onset ≥ 50 years). All patients were subjected to medical history, physical examination, disease activity measured by the SLE disease activity index (SLEDAI-2K) and a damage score. Laboratory investigations as complete blood count (CBC), serum creatinine, anticardiolipin antibodies, lupus anticoagulant, protein creatinine ratio, serum complement (C3, C4), anti-dsDNA antibody, and antinuclear antibodies (ANA).
Results: Mucocutaneous manifestations, frequency of hematuria, proteinuria, urinary cast, consumed C3, positive anti-dsDNA antibodies, anti-cardiolipin antibody and lupus anticoagulant titers had considerably greater rates in-group 1 compared to group 2 (P-value <0.05) while group 2 had significantly more musculoskeletal symptoms (P-value <0.05). The SLEDAI scores of the two groups were equivalent, however the damage index was greater in group 2 (P-value 0.00). Neuropsychiatric, cutaneous, renal, and skin damage were more frequent in group 1, while musculoskeletal, endocrinal, pulmonary, cardiovascular and ocular damage were more frequent in- group 2.
Conclusion: L-SLE is different from adult onset SLE with more frequent damage.