الفهرس 
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Abstract
Diabetes mellitus is a global emerging disease with progressive incidence
worldwide. Diabetic patients have a higher incidence of PUD than the non-diabetic
population which increased prevalence of GIT symptom and susceptibility to acute
gastric injury and impaired ulcer healing. Management of DM usually involves the
treatment of concurrent peptic ulcer. Omeprazole is one of the drugs that can be
co-administered with gliclazide in patients with DM for treatment of peptic ulcer
with the possibility of drug-drug interaction between them So, diabetic patients
treated with oral antidiabetic drugs, as gliclazide, may be also treated with
antipeptic ulcer drugs, as omeprazole.