الفهرس 
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Abstract
As a class of fat-soluble sterols, vitamin D exists in two main forms: vitamin D2, which is primarily produced by humans and added to food, and vitamin D3, which is produced by humans from 7-dehydrocholesterol and is also ingested through the consumption of animal products. Prohormone activity exists in both forms. When activated, they participate in the control of various hormones in the body, including progesterone, estradiol, FSH, and the anti-Müllerian hormone (AMH).
Additionally, there is a link between vitamin D insufficiency and PCOS because vitamin D receptors affect the levels of LH and sex hormone-binding globulin, the prevalence of insulin resistance, the levels of testosterone, and the expression of the aromatase gene. As a result, in recent years, there has been an increase in interest in examining the relationship between vitamin D insufficiency and the success of in vitro fertilization due to accumulating evidence of the involvement of VD in female human reproduction, particularly implantation.
The aim of the trial was to evaluate the effect of vitamin D supplementations on ICSI outcomes in PCO patients
This trial was conducted on 54 women undergoing ICSI who were divided randomly in to two groups
group A: Patients who received vitamin D3 as 50000 iu once every two weeks for 3months prior to and during –ICSI.
group B: Patients who went directly to ICSI cycles.
All women went through ICSI using antagonist protocol which started by 37.5–300 IU of gonadotropin on the third menstrual cycle day. The GnRH antagonist cetrorelix (Cetrotide, 0.25 mg; Serono, Geneva, Switzerland) was added daily, started when the leading follicle reached a diameter of 14 mm and continued until either the leading follicle reached a mean diameter of 18 mm or two or more follicles reached a diameter of 17 mm. Recombinant human chorionic gonadotropin (hCG) (10000IU (IBSA)) was administered subcutaneously 36 h before transvaginal oocyte retrieval.
Age, BMI, and FSH did not differ between groups in a way (p=0.286, 0.828, and 0.822) respectively.
Vitamin D levels were also 10.2-20.0 with a mean S.D. of 14.27-3.043 in group (A) and 10.5-20.0 with a mean S.D. of 14.97-2.924 in group (B), respectively, with no differences between the groups (P=0.390).
The results of our study showed no significant differences in patient’s age, BMI, FSH, vitamin D, oocyte, embryo and pregnancy outcome. However our study showed difference in outcome with vitamin D administration but this difference was not significant, as regard primary outcome.