الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
The intricate interactions between the immune system, keratinocytes, susceptibility genes, and environmental variables lead to psoriasis, a chronic inflammatory skin disorder. MicroRNAs play an important role in the pathophysiology of chronic inflammatory diseases like psoriasis, according to growing body of research.
Objectives: Our goals were to identify miRNA337’s potential as a novel marker for psoriasis.
Methodology: The dermatology clinic at Beni-Suef University Hospital conducted a case-control study on 100 volunteers, splitting them into 50 Psoriasis cases and 50 controls. Both groups’ personal histories, physical exams, and blood samples came from psoriasis patients. Blood levels of protein kinase C and miRNA337 were determined in both groups using ELIZA and real-time PCR, respectively.
Results: Blood levels of miRNA 337 were four times lower among cases compered to controls with high statistical significance (p-values >0.001). A moderate positive significant linear correlation between Blood levels of miRNA 337 with Psoriasis disease duration (r=0.301, p=0.034) among studied Psoriasis patients. Blood levels of miRNA 337 were slightly higher among males as compared with females, however this difference was with no statistically significant value (p-values >0.05). Blood levels of miRNA 337 showed non-statistically significant difference in relation to Psoriasis disease onset, course, family history nor precipitating factors (p-values >0.05).