الفهرس 
Acute LeukemiaOnly 14 pages are availabe for public view
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Abstract
Abstract
Acute myeloid leukemia (AML) is the most common type of acute leukemia in adults and is fatal as a result of primary refractoriness, relapse, or treatment-related mortality. Although the majority of patients with AML enter remission upon induction chemotherapy, the risk of relapse is considerable.
This was a prospective case control study was conducted at Ain Shams university hospitals. Clinical hematology division of internal medicine department including 60 participants: 30 adult patients with newly diagnosed AML and 30 healthy age and sex matched control. The duration of the study was 6 months.
The main findings of the study revealed that: There was no statistically significant difference between the studied groups as regard demographic data There was high statistically significant difference between the studied groups as regard BMI. According to FAB score there were 8 (26.7%) M1, 10 (33.3%) M2, 8 (26.7%) M3 and 4 (13.3%) M4. There was high statistically significant difference between the studied groups as regard WBCs, Plts, blast and ESR and statistically significant difference as regard Hb. There was no statistically significant difference between the studied groups as regard Liver and kidney function tests. There was no viral infection detected. According to Cytogenetic risk category there were 4 (13.3%) favorable, 18 (60%) intermediate and 8 (26.7%) unfavorable.
There was high statistically significant difference between the studied groups as regard ADAM-28m and ADAM-28s. ccording to MRD there were 17 (56.7%) <0.1 and 13 (43.3%) >0.1 and there were 6 who died. There was significant correlation between ADAM-28 and MRD at follow-up. Based on our findings, we recommend for further studies on larger sample size and on large geographical scale to emphasize our conclusion.