الفهرس 
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Abstract
The current study is performed to assess the effect of oral administration of curcumin
nanoparticles on the alveolar bone structure in rats with ligature induced periodontitis. This
experiment was achieved on seventy adult male albino rats divided into three groups: group
A; (control group), group B; (ligature induced periodontitis) and group C: (ligature induced
periodontitis treated with oral administration of curcumin nanoparticles).
Ligature around the right mandibular first molar was used for animals of groups B and
C to induce periodontitis and then removed after two weeks. Curcumin nanoparticles was
administrated orally to group C by using oral gavage (15 mg/kg/day) while group B was given
distilled water by the same manner 2 weeks after the induction of periodontitis which was
manifested by its clinical signs.
After 2 and 4 weeks from the time of ligature removal, animals were euthanized and the
mandible of each rat was dissected out. Right molar segments were prepared for histological
examination, histomorphometric analysis, CBCT, SEM and EDX.
Light microscopic results of the control group A revealed smooth and normal
architecture of alveolar bone with normal level of intact alveolar crest between first and
second molars in relation to the CEJ. On the other hand, microscopic examination of
periodontitis group B exhibited irregular destructed alveolar bone with marked apical shifting
of the level of the alveolar crest in relation to the CEJ. However, the LM results of group C
periodontitis treated with CURN showed regular and smooth alveolar bone with relative
restoration of the alveolar crest in relation to CEJ after 2 weeks and regaining its normal level
after 4 weeks.