الفهرس 
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Abstract
Summary Three distinctive GIT disorders that have overlapping symptoms are inflammatory bowel diseases (IBD), colorectal cancer (CRC) and irritable bowel syndrome (IBS). The early diagnosis of these situations is fundamental for their management. In the last few years there was a great concern to find the ideal non-invasive marker to substitute endoscopic examination ’’ which still considered as the gold standard’’ for the diagnosis and differentiation between different GIT disorders. As inflammatory process is a part of the pathophysiology of these disorders, some markers and ratios were supposed to be used as diagnostic tools including: fecal calprotectin a protein in neutrophil cytosol which was found to be high in a lot of GIT inflammations, systemic immune inflammation index (SII),neutrophil/ lymphocyte ratio (NLR), and platelet/ lymphocyte ration (PLR). This cross-sectional study was conducted in Tropical medicine department, Tanta University in the period between April 2021 to March 2022 after approval of Tanta university ethical committee. Informed written consent was obtained from each patient before participation in the study. One hundred patients were enrolled then they divided in three groups according to endoscopic and biopsy results; group I: included 40 patients who were diagnosed with IBD. group II: included 40 patients who were diagnosed with CRC. group III: included 20 patients who were diagnosed with IBS. All patients were subjected to the following: Detailed history-taking, full clinical examination, routine laboratory investigations including (complete blood count, ALT, AST, total bilirubin, serum creatinine), ELISA test for