الفهرس 
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Abstract
This clinical study was a prospective study performed in an isolation hospital for 296 COVID-19 patients at cardiothoracic Minia University Hospital who were recruited from February 2021 to October 2021.
All patients had been subjected to the following:
1) Full detailed history taking included (age, sex, smoking status, comorbidities and COVID 19 symptoms)
2) General and local chest examination including (respiratory rate and SpO2)
3) Investigations included:
Radiological: Non-contrast high resolution CT chest for all included patients
Laboratory: CBC (complete blood count) including absolute lymphocytic count & NLR (neutrophil lymphocytic ratio), RFTs (renal function tests) LFTs (liver function tests), inflammatory markers.
Patients were categorized into 3 groups according to WHO disease severity at time of admission as follows:
• Non-severe, severe, and critical.
• 78 group Ⅰ (non-severe), 97 group Ⅱ (severe) and 121 group III (critical).
• It was found that patients in group III were older than patients of group Ⅱ and group Ⅰ.
• As regard sex, males were significantly higher in all groups.
• As regard comorbidities, they were significantly higher in critical group.
• It was found that inflammatory markers, renal and liver function tests were impaired in COVID 19 patients especially critical cases.
• SpO2 was significantly lower in critical group, while respiratory rate was higher in critical group than others.
• Most of CT images of COVID 19 patients showed typical pattern (mostly GGO) and distribution (mostly peripheral with lower lobes predominance) but critical group show more extensive lesions than others.
• 4C mortality score at a cut-off value of 9.5 has a sensitivity 89.9% and specificity of 62.8% with AUC of 0.79, p=0.0001 in prediction of mortality. In addition, CT-severity at 12.5 score has a sensitivity of 78.9% and specificity of 60.8% with AUC of 0.77, p=0.0001 as prediction tool of mortality.
• It was found that there is a moderate to strong positive correlation between CT severity score and 4C mortality score.
• It was found that older ages> 60, male sex, hypertension, diabetes, CT severity score > 12 and 4C mortality score > 8 were significantly associated with mortality in our study.