الفهرس 
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Abstract
Hyperlipidemia is responsible for the development of coronary artery diseases, which could be treated with cinnamon and ginger.
Methods: Lipid concentrations, malondialdehyde (MDA), glutathione peroxidase (GPx), nitrite (NO2-), collagen I, matrix metalloproteinase 2 (MMP-2), tissue inhibitor of metalloproteinase 2 (TIMP-2), tumor necrosis factor alpha (TNF-α), homocysteine and histopathological examination were done in male albino rats weighing 220-250 gm. The rats were divided into five groups, kept on either control diet or high fat diet (HFD). HFD rats treated with cinnamon (one group)(400 mg/kg body weight/day), or with ginger (one group)(500 mg/kg body weight/day) and with cinnamon and ginger combination (another group) via oral route for 40 days.
Results: Hyperlipidemic control (HC) rats which fed on a HFD, developed hypercholesterolemia, hypertriglyceridemia, increased LDL-C, MDA, NO2-, collagen I, MMP-2 and decreased HDL-C, GPx, TIMP-2 when compared to rats fed on control diet. Treatment of the HFD rats with either cinnamon or ginger alone caused a significant decrease in triacylglycerol (TAG), total cholesterol, LDL-C, MDA, NO2-, collagen I, MMP-2, and a significant increase in HDL-C, GPx, TIMP-2. The combined treatment caused a prominent significant difference between groups.
Conclusion: Hyperlipidemia could induce coronary artery diseases and that combined treatment had a great protective role against the metabolic abnormalities better than the treatment with either cinnamon or ginger alone.