الفهرس 
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Abstract
Background:
The effect of bleeding disorders and its treatment on HRQOL in children and adolescents are conflicting. Current treatment strategies have ensured that pediatric patients with bleeding disorders can now anticipate a normal life expectancy so, assessment of quality of life (QOL) in patients with bleeding disorders is important for the disease outcome.
Aim of the Work: To assess HRQOL, in adolescent aged 13-18 years with bleeding disorders compared to peers.
Patients and Methods: A case control study was conducted on 156 participants, 78 control (age and sex matched) and 78 bleeding disorders patients through a period from October 2020 to September 2021.
Results: The current study revealed statistically significant impairment in school performance among patients with bleeding disorders with p-value<0.001. There was positive correlation between severity of hemophilia patients and physical health with p-value=0.029. Most of ITP patient had mild ITP (53.8%). There was impaired total psychological score, with p-value=0.040, physical health with p-value=0.037 among severe ITP patients compared to mild and moderate ITP patients.
Conclusion: Different bleeding disorders including Hemophilia, ITP, and Von Willbrand disease have negative impact on quality of life including physical health, emotional, social, and psychological and school performance which differ according to degree of severity. In which both children and caregivers make sacrifices in their daily lives.