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العنوان
Evaluation of the effectiveness of the use of Calcium gluconate, Cabergoline and Gnrh agonist in prevention of OHSS in PCOS patients during ICSI procedures /
المؤلف
El-kashef, Abdulrahman Yehia Mohammed.
هيئة الاعداد
باحث / عبد الرحمن يحيي محمد الكاشف
مشرف / عصام إبراهيم علي
مشرف / مؤمن محمد محمد حسن
مشرف / أحمد ربيع عبد الرحيم
مشرف / هيثم أحمد بهاء الدين
الموضوع
Polycystic ovary syndrome. Ovaries - Diseases.
تاريخ النشر
2022.
عدد الصفحات
144 p. :
اللغة
الإنجليزية
الدرجة
الدكتوراه
التخصص
أمراض النساء والتوليد
تاريخ الإجازة
1/1/2022
مكان الإجازة
جامعة المنيا - كلية الطب - أمراض النساء والتوليد
الفهرس
Only 14 pages are availabe for public view

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Abstract

Ovarian hyperstimulation problem (OHSS) is an iatrogenic ensnarement achieved by exogenous hCG for setting off in helped conceptive strategies (ART) cycles or endogenous release from placenta during the pregnancy. Notwithstanding the way that it has been recognized to be self-limited in the vast majority of cases, hospitalization can be anticipated in 2% of all in vitro treatment (IVF) cycles. The general passing rate for OHSS is surveyed to be 3/100.000. (9) (183)
Evasion:
There are two kinds of expectation modalities for OHSS. Fundamental evasion systems portray the plan to choose fundamental bet components of the patient right away and a while later designating the best treatment and show of COH that conveys the most insignificant bet. Discretionary evasion portrays the framework that endeavors to leave the bet of OHSS when helper bet factors turned out to be clear during COH.
The continuous audit selected 150 PCOs patients, and inclined to be hyperresponders, who went through ICSI methodology. Patients were organized into three social occasions with 50 patients in each get-together.
• Bundle A: were given the standard HCG trigger 10,000 IU of hCG (Choriomon) notwithstanding IV combination of 1 ampoule Calcium gluconate (Calcionate 10 ml 10% calcium gluconate, Memphis) in 200 ml physiologic saline inside 30 min. of ovum pickup and happened for the accompanying 3 days.
• Pack B: were given the ordinary HCG trigger 10,000 IU of hCG (Choriomon) notwithstanding Cabergoline (Dostinex 0.5mg, Pfizer, Montreal, Canada) 0.5mg orally for 7 days following a surprisingly long time of trigger.
• Bundle C: were given 0.2 mg of GnRh agonist (Decapeptyl 0.1mg, Ferring) as a trigger.
Patients’ ages, infertility term, justification behind unproductiveness, measurements of HMG, AFC, length of enrollment cycle and levels of AMH, showed no colossal quantifiable difference.
The current investigation discovered that in group A there were 62% synthetic pregnancy rate, in group B, was 56%, 84% in group C. Then again, in group A there were 52 % clinical pregnancy rate, in group B, was 44%, 78% in group C.
As to rates of OHSS, early OHSS was found in 32%, 24%, 12% in group A, B, C separately. While following 10 days, late OHSS was seen in 10% of Calcium bunch and 20% for the Cabergoline bunch and 42% with Decapeptyl. With respect to level of OHSS, the most elevated frequency of Mild structure was archived in Calcium bunch by 28% of patients. While Severe structure was least with Calcium (4%). Thus, Calcium Gluconate is recommended to be more powerful in the anticipation of Severe OHSS than Cabergoline and Decapeptyl.