الفهرس 
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Abstract
Ciprofloxacin is an antibiotic that is used to treat different bacterial infections such as upper and lower respiratory infections, sexually transmitted diseases, and some skin, bone, and soft tissue infections, as well as community-acquired pneumonia.
Renal damage caused by ciprofloxacin could be fatal. This includes glomerulonephritis, acute uric acid nephropathy and acute renal failure.
It is known that antioxidants may help to diminish the drug’s potentially harmful effects.
Olive oil has antioxidant properties and contains vitamin E, oleocanthal, carotenoids, and polyphenols are of the powerful antioxidants.
The present work aimed to evaluate the histopathological and ultrastructure changes induced by ciprofloxacin on the rat kidney tissue to investigate the possible protective role of olive oil.
The present study was carried out on forty adult male albino rats, with average weight of 150-200 gm. The rats were divided equally into five groups ( eight rats for each) ; group I: Control rats given food and water without restraint during the experimental period. group II: rats received virgin olive oil (5 ml/Kg body weight) daily by orogastric tube for fourteen days at 10 a.m. group III: rats received ciprofloxacin (20 mg/Kg body weight) dissolved in 8 ml of distilled water daily by orogastric tube for fourteen days at 10 a.m. group IV: Combined group; the rats received both ciprofloxacin and olive oil as the previously described doses. group V: Recovery group; the rats received first ciprofloxacin for fourteen days then followed by olive oil for fourteen days as the previously described doses then sacrificed after one month from the end of experimental period.