الفهرس 
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Abstract
Summary
Acne vulgaris (acne) is one of the most common chronic dermatological diseases among adolescents, affecting about 80% of young people between 12 and 18 years of age. The severity of acne is characterized by the number of non-inflammatory closed and open comedones, inflammatory pustules and papules, as well as residual pathology like nodules and cysts.
Despite its high prevalence, the exact pathophysiology of acne remains unknown but is believed to be multifactorial, including genetic predisposition, hormonal disturbances, abnormal hair follicle keratinization, skin colonization by Priopionibacterium acne, and disturbances in sebum production.
Recent findings also support the influence of lifestyle on the disease, indicating that intake of high glycemic index foods may have a profound effect on the development and severity of acne. These observations could be of great importance as the number of overweight adolescents continues to increase despite increasing knowledge about risks resulting from obesity.
Adipokines are small molecular weight biologically active proteins primarily produced by adipocytes, however many members are expressed and secreted also by non-adipocyte cells. The roles of adipokines in regulating inflammatory responses in adipose tissues and systemic organs become evident during the development of obesity and in response to infection or systemic inflammation. An increasing number of studies have identified the relationship between various adipokines and Acne vulgaris.
Obesity is characterized by a generalized change in the levels of circulating adipokines due to abnormal accumulation and dysfunction of adipose tissue. Altered adipokine levels underlie complications of obesity as well as the increased risk for the development of obesity-related comorbidities such as type 2 diabetes, cardiovascular and neurodegenerative diseases.
The study is aimed to evaluate serum level of adiponectin in post-adolescent acne and its relation to body mass index.
This study is Case control study, was conducted at Dermatology Outpatient Clinic at Beni-Suef University Hospital, on 120subjects (60 patients with acne and 60 normal subjects as control), from December 2019- August 2020.
The main results of the study revealed that:
There was significant difference between both groups as regard age.
There was significant difference between both groups as regard height.
The mean Duration of the disease was 3.93 (±2.85 SD), the mean GAGSwas 23.48 (±11.02 SD),there were 20 mild, 15 were moderate, 15 severe and 10 were very severe.
There was high significant difference between both groups as regard Fasting glucose.
There was insignificant difference between both groups as regard Lipids metabolism.
There was significant difference between both groups as regard Adiponectin 120 and as regard Leptin.
There was high significant difference between both groups as regard adiponectin /leptin ratio.
There was a statistically significant negative correlation between serum adiponectin level and serum LDL-C level (r=-0.340*, p=0.008*).
Based on our results we recommend for further studies on larger patients and longer period of follow up to emphasize our conclusion.