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العنوان
Role of Adjuvant Mitomycin C In The Endoscopic Treatment of Laryngotracheal Stenosis
(Meta-analytic Study)
/
المؤلف
Ahmed,Mohamed Shokry Hassan
هيئة الاعداد
باحث / محمد شكرى حسن احمد
مشرف / هشام صلاح الدين الحلبي
مشرف / هشام عبد العاطي السرسي
مشرف / عمرو حامد محمد
تاريخ النشر
2022
عدد الصفحات
125.p:
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
الحنجرة
تاريخ الإجازة
1/1/2022
مكان الإجازة
جامعة عين شمس - كلية التمريض - Otorhinolaryngology
الفهرس
Only 14 pages are availabe for public view

from 125

from 125

Abstract

Background: Laryngotracheal stenosis is a life-threatening restriction in pulmonary ventilation. It is an umbrella term, including luminal compromise at the level of the larynx, subglottis, or trachea. Etiology of laryngotracheal stenosis is multifactorial. In adults and adolescents it is mostly acquired, where in children it may be acquired or congenital. Acquired laryngotracheal stenosis can result from previous intubation or tracheostomy, systemic disease, trauma, infection, or idiopathic causes. Historically, infectious etiology was common. Currently, laryngotracheal stenosis most frequently results from prolonged intubation or trauma from intubation itself.
Objective: To evaluate the effectiveness of topical Mitomycin C as an adjuvant treatment with the endoscopic management of laryngotracheal stenosis.
Patients and Methods: The total number of patients in all the included studies was 454, 379 patients in MMC group and 75 patients in non-MMC group.
Results: This meta-analysis study showed that resolution (success) rate in MMC group was (68.7%) and there was a significant increase in resolution (success) rate in MMC compared to non-MMC group (p = 0.011) with the odds of being 5 times higher in MMC group (OR=5.04). The Complications rate in MMC using patients was (4%). The result of this meta-analysis study showed that Mitomycin C is an effective and safe adjuvant in the endoscopic treatment of laryngotracheal stenosis. However, this study included limitations. We recommend the need of more high quality prospective randomized controlled trials, two armed studies and further studies in the future to achieve stronger results.
Conclusion: We suggest that that Mitomycin C is an effective and safe adjuvant in the endoscopic treatment of laryngotracheal stenosis. However, this study included limitations. We recommend the need of more high quality prospective randomized controlled trials, two armed studies and further studies in the future to achieve stronger results.