الفهرس 
IntroductionOnly 14 pages are availabe for public view
 |  | from | 122 |  |  |
| | | from | 122 | | |
Abstract
Osteoporosis and osteopenia are one of the major skeletal diseases worldwide and possess a great health burden. Several risk factors can participate in the pathogenesis of osteopenia and OP. In addition, various chronic disease are complicated with decreased bone mass and subsequent increased liability to fractures.
Chronic dermatological diseases were reported to be associated with several degrees of decreased bone mass as for example psoriasis and vitiligo. In the current study we aimed to evaluate the prevalence of osteopenia and osteoporosis in some chronic skin diseases.
We included 100 patients diagnosed with chronic primary dermatological diseases divided into 4 groups according to dermatological disease (33 patients had vitiligo, 27 patients had psoriasis, 24 patients had chronic urticaria and 16 patients had atopic dermatitis).
All included patients were subjected to full history recording, general and dermatological examination, assessment of BMD by DEXA scan and estimation of serum level of vitamin D.
Summary
88
Regarding DEXA scan analysis, of included patients 35 patients had osteopenia (11 vitiligo patients, 11 psoriasis patients, 7 chronic urticaria patients, 6 atopic dermatitis patients), 12 patients had OP (3 vitiligo patients, 4 psoriasis patients, 2 chronic urticaria patients, 3 atopic dermatitis patients) and 53 patients had normal DEXA scan. Vitamin D analysis revealed that 3 patients had deficient levels (all chronic urticaria patients), 70 patients had insufficient levels (23 vitiligo patients, 18 psoriasis patients, 18 chronic urticaria patients, 11 atopic dermatitis patients) and 27 patients had sufficient levels of vitamin D.
In vitiligo patients, there was significant association of insufficient vitamin D levels. DEXA scan results (T score) revealed no statistically significant difference, in addition there was no significant difference in DEXA scan results regarding vitiligo severity.
In psoriasis patients, there was significant association of insufficient vitamin D levels. DEXA scan results (T score) revealed no statistically significant difference, in addition there was no significant difference in DEXA scan results regarding psoriasis severity.
In chronic urticaria patients, there was significant association of insufficient vitamin D levels. DEXA scan
Summary
89
results (T score) revealed no statistically significant difference, in addition there was no significant difference in DEXA scan results regarding chronic urticaria severity.
In atopic dermatitis patients, there was significant association of insufficient vitamin D levels. DEXA scan results (T score) revealed no statistically significant difference, in addition there was no significant difference in DEXA scan results regarding atopic dermatitis severity.
Correlation of age with different T scores revealed statistically significant negative correlation with forearm T score in patients with vitiligo, psoriasis and chronic urticaria. Correlation of vitamin D levels with different T scores revealed statistically significant positive correlation with lumbar T score in patients with psoriasis. However, comparison of age, age of onset, duration of skin disease, vitamin D levels and different T scores across all patients’ groups revealed no statistically significant difference