الفهرس 
TUMOUR METASTASISOnly 14 pages are availabe for public view
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Abstract
Cancer is the second leading cause of death in developed countries, is among the three leading causes of death for adults in developing countries, and is responsible for 12.5% of all deaths worldwide. Once a malignant tumor is detected, determination of disease extent (staging) is important for appropriate treatment planning and determining prognosis. Imaging plays a pivotal role in cancer staging. Furthermore, imaging is of great importance in monitoring response to therapy and in the detection of tumor recurrence. (75)The clinical implementation of whole body diffusion weighted imaging (WB-DWI) for tumor-detection, -characterization and therapy monitoring is well underway. The method is fast, robust and combined with its wide availability on modern MRI scanners, it has a vast potential clinical impact. Owing to the high tumor to background contrast, its main application areas are simple detection of tumor suspicious lesions (primary tumor, recurrence, and metastasis), tumor grading and therapy monitoring. WB-DWI has a strong diagnostic potential regarding the evaluation of bone marrow and its diseases and as thus, tumor detection and therapy monitoring of bone metastasis is of particular interest. spreading is constricted. One of the major hurdles that still hamper the wide clinical application of WB-DWI is a lack of standardization of measurement parameters that limit the comparability of current research results.