الفهرس 
Health-related quality of life In children with sickle cell disease
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Abstract
Background: Sickle cell disease (SCD) is a chronic disease associated with increased morbidity and mortality. Hemoglobinopathies are the most prevalent genetic disease globally. Sickle cell disease impacts the physical, emotional and psychological aspects of life of the affected persons and alters the health related quality of life. Objective: The purpose of this study is to assess health-related quality of life in children with sickle cell disease. Materials and Methods: A cross-sectional descriptive study with the aid of a structured interview administered two questionnaires (CHQPF50- CHQ-CF87) was conducted among 60 child and parents attending at hematology clinic {u2010}Cairo University children{u2019}s hospital. Results: The mean age of the subjects was 14 years (± 3.45). Thehighest scores in children’s response to PHQ-CF87 were the mean Physical Functioning, Role/Social limitations :( Emotional, Behavioral, Physical), Global Behavior Item, Family Activities, and Family Cohesion scales with significant inverse correlation between children’s age and Role/Social limitations: Emotional/Behavioral, Global Behavior Item, mental health, Self Esteem and General Health Perceptions scales. While that there were no significant relation between children’s gender and any of PHQ-CF87 scales. no statistically significant differences in the mean CHQ-CF87 scales across children’s education levels, except for the GBE and MH scales. Children with middle institute education had significantly lower GBE scale compared to those with primary or secondary education