الفهرس 
Title :Measurement of Klotho as a marker of osteoporosis in Egyptian sickle cell disease patients
صفحة العنوان باللغة العربيةOnly 14 pages are availabe for public view
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Abstract
Introduction: Bone and joint disorders are the most common cause of chronic pain in sickle cell disease patients with many complications including osteopenia and osteoporosis. Klotho protein, whose gene has predominant renal expression, acts in the control of serum phosphorus and 1,25-dihydroxyvitamin D3 which may be implicated in onset of osteopenia and osteoporosis. Objective: Our study aimed to measure serum Klotho level by enzyme linked immune sorbent assay as a marker of osteoporosis in sickle cell disease patients in correlation with Dual Energy X- ray Absorptiometry scan. Patients and methods: This was a cross-sectional study which included 60 (sixty) sickle disease patients who were performing routine follow up at the Hematology clinic of children Hospital Cairo University in addition to 30 (thirty) age and sex matched healthy control subjects .All of the included patients were subjected to full history taking, examination, investigations including Dual Energy X-ray Absorptiometry scan and Klotho level