الفهرس 
Title : The possible effects of zileuton and celecoxib on liver regeneration in partial hepatectomized rats
ContentsOnly 14 pages are availabe for public view
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Abstract
The implication of prostaglandin E2 (PGE2) and thromboxane A2 (TXA2) in the striking process of liver regeneration has been previously reported. However, their exact roles and downstream signals haven’t been utterly revealed. Therefore, the present study was conducted to explore the possible promoting effects of PGE2 and TXA2on hepatocytes proliferation after partial hepatectomy (PHx) in rats and also to determine which one has the upper hand. In order to achieve these goals, the modulating effects of celecoxib, a specific COX-2 inhibitor, zileuton, a specific leukotriene inhibitor and seratrodast, a TXA2receptor anatgoinst, on liver regeneration were examined in the current study. Celecoxib (20 mg/kg/day), zileuton (25 mg/kg/day) and seratrodast (2 mg/kg/day) were given orally 1 h before PHx and then daily till the end of experiment (1, 3 or 7 days after the operation). Interestingly, celecoxib or zileuton treated rats showed a further increase in interleukin-6, p65 nuclear factor mB and phosphorylated signal transducer and activator of transcription 3 as compared to PHx control rats. Furthermore, the liver contents of growth factors as well as Ý-catenin and cyclin D1protein expressions were also enhanced by both drugs. Accordingly, celecoxib or zileuton significantly improved hepatic proliferation as indicated by the increase in Ki67 expression and liver index. However, zileuton showed more obvious results compared to these of celecoxib. Contrariwise, seratrodast hindered the normal regeneration process and completely abolished the proliferative effect of celecoxib or zileuton