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العنوان
Design and synthesis of certain novel benzenesulfonamide derivatives with anticancer activity /
الناشر
Mohamed Adel Sayed Mahmoud ,
المؤلف
Mohamed Adel Sayed Mahmoud
هيئة الاعداد
باحث / Mohamed Adel Sayed Mahmoud
مشرف / Sahar M. Abouseri
مشرف / Dalia H. Soliman
مشرف / Samar H. Fahim
تاريخ النشر
2020
عدد الصفحات
182 P. :
اللغة
الإنجليزية
الدرجة
الدكتوراه
التخصص
العلوم الصيدلية
تاريخ الإجازة
22/9/2020
مكان الإجازة
جامعة القاهرة - كلية الصيدلة - Pharmaceutical Chemistry
الفهرس
Only 14 pages are availabe for public view

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from 217

Abstract

Cancer is one of the leading causes of death across the world, causing great stress to human life. Chemotherapy emerged to be important key player in the treatment of many of cancer patients ranging from primary to advanced stages. However, the severe side effects, poor tolerance and the development of resistance to chemotherapeutic drugs limited their use in many patients. Therefore, the development of novel, efficient, and less toxic anticancer agents remains a serious and challenging goal for the medicinal scientists worldwide. One of the most powerful discovered anticancer scaffolds is the benzenesulfonamide moiety attached to triazole or pyrazole rings. Therefore, the present study deals with the synthesis of different series of benzenesulfonamides hybridized with triazoles, fused triazoles and fused pyrazoles either through direct connection or via azo (-N=N-) spacer furnishing