الفهرس 
The prospect of using serum taurine level as a potential biomarker for early detection of colorectal carcinoma and its correlation with other prognostic markers
احتمالية استخدام مستوى التورين بالدم كدلالة بيولوجية محتملة للكشف المبكرعن سرطان القولون و المستقيم و ارتباطه بالدلالات الاخرىOnly 14 pages are availabe for public view
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Abstract
Background:Colorectal carcinoma is the third leading cause of cancer-related deaths in the USA, resulting in an estimated of more than 49,000 deaths in 2016, and estimated 1.4 million cases and 693,900 deaths occurring in 2012 worldwide. In Egypt, it remains a massive problem as about 40% of cases occur in individuals under 40years of age. Current studies have proposed that changes in systemic taurine levels can be used to predict the formation and malignant transformation of certain tumors. Also, recent studies showed that it could be used as an early biomarker in breast cancer, uterus cancer, diabetic retinopathy, liver fibrosis, and hepatocellular carcinoma. Aim:Investigate the probability of using serum Taurine level as a pre- early biomarker for colorectal carcinoma, especially in the precancerous condition in Egyptian patients. Moreover, comparing serum Taurine level and specific biomarkers before and after surgical treatment. Patients and methods:from a lot of Egyptian patients attended to National Cancer Institute, Cairo University, presented with abdominal troubles and gastrointestinal problems; after full examination and diagnosis; one-hundred and six patients -after their approval- were classified into three groups: the first group consists of ninety-one patients were diagnosed with colorectal carcinoma with various stages, the second group is involving eight patients were diagnosed as benign tumors, and the third group including only seven patients were diagnosed with Specific chronic Inflammation diseases. Ten healthy volunteers enrolled as a frank control. For the first group and second group, serum Tau measured preoperatively (a day before the operation) and postoperatively (after 45 days from the operation)