الفهرس 
Ultraviolet phototherapy versus vitamin d supplementation : Effects on cognitive functions, fatigue and serum neurofilament level in relapsing remitting multiple sclerosis patients
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Abstract
Background: Ultraviolet radiation (UVR) may affect many processes in human body independent of vitamin D production. Vitamin D has a role as a neuroprotective agent that supports memory, cognition and neuroplasticity. Up to 92% of MS patients are affected by fatigue, which strongly influences their quality of life. Neurofilament light chain (NFL) may act as a biomarker of subclinical activity and inflammation. Objective: to compare the impact of Broadband ultraviolet B radiation (BB-UVB) therapy to vitamin D3 supplementation on disability, cognitive functions and fatigue in relapsing remitting multiple sclerosis (RRMS) patients and to evaluate their effect on serum neurofilament light chain (sNFL) level. Subjects and methods: Forty RRMS patients were divided equally into two groups; UVR group received BB-UVB radiation (3 sessions weekly for 4-weeks) and D3 group received vitamin D3 supplement (50,000 IU weekly for 3-months).Comprehensive cognitive battery: MoCA (Montreal Cognitive Assessment), SDMT (Symbol Digit Modalities Test) and BVMT-R (Brief Visuospatial Memory Test-Revised), FSS (Fatigue Severity Scale) were done. Blood samples were taken to measure serum levels of vitamin D3 and NFL at baseline and 3-months after supplementation