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Abstract
Introduction: Neonatal jaundice occurs in up to 85% of all live births. Severe hyperbilirubinemia makes infants at considerable risk of potentially dangerous bilirubin encephalopathy with subsequent kernicterus.The aim of the current study was to assess the incidence of acute bilirubin encephalopathy and study various risk factors for acute bilirubin encephalopathy (ABE). Aim of the work: was to assess the incidence of acute bilirubin encephalopathy and study various risk factors for acute bilirubin encephalopathy (ABE). Methods: The study was a prospective cohort study conducted on 100 term neonates ({u2265} 37 weeks) with severe neonatal hyperbilirubinemia ({u2265}20 mg/dl) admitted at neonatal intensive care unit (NICU) of Cairo University Children Hospital (CUCH) in the period from June 2018 to Febreuary 2019. All the studied neonates were subjected to: thorough history taking (antenatal, natal and postnatal history), full clinical examination including BIND score (on admission and discharge) and laboratory investigations including serum bilirubin, complete blood count, blood group of the baby and the mother, reticulocyte count, Coomb{u2019}s test