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العنوان
A pharmacognostical study of canna x generalis L.H. Bailey, family cannaceae, cultivated in Egypt /
الناشر
Toka Nael Omar Abdelaziz Mahmoud ,
المؤلف
Toka Nael Omar Abdelaziz Mahmoud
هيئة الاعداد
باحث / Toka Nael Omar Abdelaziz Mahmoud
مشرف / Nabaweya M. Elfiky
مشرف / Zeinab A. M. Kandil
مشرف / Taha S. M. A. Elalfy
تاريخ النشر
2019
عدد الصفحات
229 P. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
العلوم الصيدلية
تاريخ الإجازة
9/1/2020
مكان الإجازة
جامعة القاهرة - كلية الصيدلة - Pharmacognosy
الفهرس
Only 14 pages are availabe for public view

from 274

from 274

Abstract

Canna x generalis (family Cannaceae) is a rhizomatous large hybrid herb, native to Central and South America. It is cultivated in Egypt for ornamental usage. Members of genus Canna were traditionally used as demulcent, diaphoretic, antipyretic, diuretic, antimicrobial and in the treatment of gastrointestinal upset. Canna rhizomes have been used for food and as a source of commercial starch. The aim of this work is to explore the botanical features, phytoconstituents, as well as the biological activities of the plant. Botanical study of different organs; leaf, stem, rhizome and root, was performed on both entire and powdered forms to determine the main diagnostic features that aid in their identification. The main phytoconstituents of leaves and rhizomes were screened and proved the presence of sterols and/or triterpenes, carbohydrates and/or glycosides, flavonoids and tannins. UHPLC/qTOF-HRMS analysis of the methanol extracts of the two organs resulted in identification of 74 and 39 metabolites, respectively. Lipoidal matter were analysed by GLC. Total phenolic, flavonoid and sterol contents were estimated spectrophotometrically. Three and five compounds were isolated and characterized from leaves and rhizomes, respectively. Antioxidant activity was investigated using DPPH for ethanol extracts and their fractions of both organs. Highest activity is recorded for rhizomes methylene chloride and leaves ethyl acetate fractions. Anti-inflammatory activity was also assessed by two in-vitro models; histamine release inhibition and albumin denaturation inhibition.