الفهرس 
Oncological outcome of osteosarcoma patients above 40 years treated by limb Salvage surgery and neoadjuvant chemotherapy
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Abstract
Osteosarcoma is the most commonly diagnosed primary malignancy of bone, especially in children and adolescents. Osteosarcomas in elderly patients mostly are secondary neoplasms related to sarcomatous transformation of Paget disease of bone or other benign bone lesion. In elderly, tumors occur more commonly in axial sites and in areas that have been irradiated previously or that have underlying bone abnormalities. Some studies have demonstrated the local recurrence incidence after limb resection was higher by four times than that after amputation. Other studies demonstrate no difference in the incidence of local recurrence between patients who were treated by amputation and those treated by limb salvage. In our study, we evaluated the oncological outcome of osteosarcoma patients above 40 years treated by limb salvage surgery and chemotherapy. A retrospective analysis of prospective study was done in the Center for Preservation and Transplantation of Musculoskeletal Tissues (CPTM) - Alkasr Alainy Hospital. We reviewed 25 records of patient with osteosarcoma above 40 years old between 2000 and 2017. Eleven patients were lost follow up