الفهرس 
TitleOnly 14 pages are availabe for public view
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Abstract
A single exposure to TTFs can work as a new cancer therapeutic technique with a
death percentage of 8–17% according to the cancer type. TTFs mechanism of action does
not include ROS production. ZnO NPs have a great anti-cancer effect, its IC50 varies from
one cancer type to another. Its lethal effect is mainly due to ROS generation. The synergetic
effect of TTFs and sub-lethal ZnO NPs increases the lethal percentage to be about 20–33%
according to the cancer type without an increase in ROS production. The results of this
research can lead to the use of smaller concentrations of NPs as well as improving the TTFs
technique against different cancer cell types. Increasing the potency of the NPs using TTFs
can be a novel technique in many biomedical applications. Decreasing the number of used
NPs has environmental and industrial importance.
Author Contributions: Conceptualization, M.M.S., A.E.S., S.E. and M.E.M.; methodology, M.M.S.,
A.E.S., S.E. and M.E.M.; formal analysis, M.M.S. and S.E.; resources, M.M.S., A.E.S., S.E. and M.E.M.;
data curation, M.M.S. and S.E.; writing—original draft preparation, M.M.S., A.E.S. and M.E.M.;
writing—review and editing, M.M.S. and S.E.; supervision, M.M.S., S.E. and M.E.M.; funding acquisition,
M.M.S., A.E.S., S.E. and M.E.M. All authors have read and agreed to the published version of
the manuscript.
Funding: This research received no external funding.
Molecules 2022, 27, 4384 11 of 13
Data Availability Statement: The data presented in this study are available upon request from the
corresponding author.
Conflicts of Interest: The authors declare no conflict of interest.
Sample Availability: Samples of the ZnO NPs and all the used cancer cell lines are available from
the authors.