الفهرس 
Aggresome definition and Aggresome pathwayOnly 14 pages are availabe for public view
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Abstract
Childhood medulloblastoma is one of the most common aggressive brain tumors. Decade ago, introducing the molecular stratification of medulloblastoma patients into four molecular subgroups improved prediction of patients‟ outcome. Although, the considered molecular staging systems have improved treatment stratification, they still require further subclassification to identify high-risk patients. In this study, we investigated the presence of aggresomes in 93 pediatric medulloblastoma tissue samples and examine their impact on survival outcomes. Aggresomes are cage-like structures formed by the collapse of the intermediate filament; vimantin, around misfolded proteins. They are considered a cytoprotective mechanism to maintain cellular proteostasis. They had been implicated in the pathophysiology of many neurodegenerative diseases. However, there was no reports investigating whether aggresomes might be recognized as a pathogenic feature in pediatric medulloblastoma