الفهرس 
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Abstract
Inflammatory bowel disease (IBD) is an idiopathic disease characterized by severe inflammation of the gastrointestinal tract. It encompasses two major clinical entities: ulcerative colitis (UC) and Crohn’s disease (CD). Although, the exact etiology in IBD remains uncertain, it is generally caused by an immunological imbalance in the intestinal mucosa, which is often mediated by an inappropriate and sustained inflammatory response against environmental factors and commensal pathogens in genetically susceptible hosts. IBD is profoundly associated with extraintestinal manifestations that have become more frequently diagnosed among patients with CD or UC. Renal complication is considered as one of the EIMs and accounts for 4% - 23% of IBD patients. The most commonly encountered renal diseases in patients with IBD are: glomerulonephritis, tubulointerstitial nephritis, nephrolithiasis and amyloidosis. The association of kidney diseases with IBD has been reported in many clinical and experimental studies; however, the underlying mechanism(s) are not fully elucidated. The current study was done to assess whether patients with inflammatory bowel disease have some degree of renal involvement and also to determine if associated with disease activity or not. A total of 121 patients who were confirmed to have inflammatory bowel disease were enrolled in the study. A total of 20 (16.5%) patients were found to had kidney disease while the other 101 (83.5%) patients didn’t have kidney disease. It was found that patients with kidney disease had significantly younger age at time of diagnosis (36.40 ± 9.66 vs. 29.65 ± 8.19) and longer disease duration (2.63 ± 1.28 vs. 4.11 ± 2.47) in comparison to those without kidney disease. Also, patients with kidney disease had significantly higher frequency of family history of chronic kidney disease (9 (45%) vs. 3 (3%)).It was found that both groups had insignificant differences as regard baseline laboratory data with exception of significantly lower serum albumin and glomerular filtration rate and significantly higher c-reactive protein, blood urea, serum creatinine and proteinuria among patients with kidney disease. Based on the current study, predictors of kidney disease in patients with inflammatory bowel disease were younger age of diagnosis, duration of the disease and family history of chronic disease. In conclusion; 20 out of 121of IBD patients had renal affection in form of raised blood urea,s.creat and lower level of eGFR and abnormal urinary contents especially proteins. All patients with IBD should monitor their renal function for early detection of renal involvement and proper management.