الفهرس 
IntroductionOnly 14 pages are availabe for public view
 |  | from | 160 |  |  |
| | | from | 160 | | |
Abstract
Treatment of breast cancer with doxorubicin causes numerous side effects like cardiac and renal fibrosis. Pirfenidone and vitamin D have been shown to possess anti-fibrotic and anti-inflammatory activities, however, the use of these drugs to protect or ameliorate the fibrotic effects of doxorubicin in cancer models are yet unclear and additional pathways need to be explored. This study aimed to investigate the underlying molecular mechanisms for the potential anti-fibrotic effect of pirfenidone and vitamin D against doxorubicin-induced cardiac and renal fibrosis.