الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Advanced glycated end products (AGEs) have attracted significant interest in the last few decades as one of the numerous processes for aging; their gradual buildup in the body over time causes significant morbidity and mortality.
At the start of the 20th century, the traditional Maillard reaction led to the early discovery of the heterogeneous group of chemicals known as AGEs and it was recognized as accurate biological age markers
Higher AGE concentrations have been linked in multiple studies to a deterioration in physical function.
Sarcopenia, or the loss of muscle size, is a significant contributor to underlying physical limitations in elderly people, such as sluggish speed.
The mechanisms of musculoskeletal tissue ageing include enhanced cross-linking of collagen by advanced glycation end products and reduced tissue regeneration ability after injury.
AGEs enhance oxidative stress and inflammatory cytokines. Additionally, AGEs cause the degradation and crosslinking of muscle protein in aged people.
Age-related increases in AGEs receptor expression in muscle fibers imply that intracellular AGEs-AGEs receptor signaling is enhanced in the muscle of aged people. A human investigation revealed that the deposition of AGEs in muscle fibers causes collagen cross-links, which accelerate muscular stiffness and decreases the power of muscle contraction. Thus, it is hypothesized that AGE accumulation levels in aged people are linked to sarcopenia and a loss of muscle mass.
Our study aim was to assess the possible contribution of advanced glycated end products (AGEs) in motor dysfunction in the elderly.
This study was conducted on 50 older males aged 65 years old and above they were divided into 2 groups (group 1): the control group which included 20 subjects had normal hand grip strength and normal walking speed and (group2): the cases group which included 30 of subjects had abnormal hand grip strength and slow walking speed. A detailed history was taken, and routine investigations were done to all subjects then they were prospectively assessed by geriatric screening tests (MNA, timed up and Go Test, ADL, MMSE), assessment of hand grip strength using a hand dynamometer, and measurement of serum carboxy-methyle lysine (CML).
In the present study, CML showed a positive correlation with age in both studied groups with a p-value (<0.001) and a positive correlation with the TUG test in both studied groups with p-value (0.002) in group 1 and (0.003) in group 2. It showed also a positive correlation with MNA in group 2 with a p-value (0.033). And negative correlation with hand grip strength in both studied groups with a p-value (<0.001).
According to our study age is the most significant independent variable of CML. TUG test, hand grip strength are cofounder their scores changed according to CML but with no significant effect in regression analysis.