الفهرس 
1. IntroductionOnly 14 pages are availabe for public view
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Abstract
This study aimed to investigate the effect of Garcinia cambogia peels powder and its extract on biomarkers of obesity among experimental rats. Thirty adult albino rats (weighting 140 ±10 g) were divided into 2 main groups, the first main group (5rats) feed on standard diet and tap water as control negative group (C-ve), and the second main group is experimental group (n= 25 rats) and this group was fed on high fat diet (20% animal fat) for four consecutive weeks to induce obesity. Then was further subdivided into 5 groups (n= 5 rats each group); the 1st group Obese rats (untreated group) induced by fed on high fat diet (20% animal lipid) as a control positive group (C+ve), the 2nd group obese rats fed on Garcinia cambogia powder by 0.5% diet, the 3rd group obese rats fed on Garcinia cambogia powder by 1% diet, the 4th group obese rats fed on Garcinia cambogia powder by 1.5%diet,. and the 5th group obese rats injected with Garcinia cambogia alcoholic extract by 250mg/kg body weight per day. The intervention continued for 28 consecutive days. At the end of the experiments period, body weight gain, feed intake , feed efficiency ratio and relative organs weight were evaluated. Also, blood samples were analyzed for determination of serum liver enzymes (AST, ALT and ALP), blood lipid profile (Triglycerides, Total Cholesterol, LDL, HDL, VLDL), kidney functions (uric acid, urea and creatinine). Also, liver and kidney were observed for histopathological examinations. Obesity led to a significant (P ≤ 0.05) increase was recorded in TC, TG, VLDL, LDL, Urea, Creatinine, U.A , AST, ALT , ALP and Glucose, while a significant (P ≤ 0.05) decrease in the level of HDL. Obese rats were fed on different diets and the results showed a marked improvement in all the different indicators. Finally results indicated that the best group was recorded for group(5) (1.5% G.C powder) and group (6) (250mg\kg alcoholic extract). It is therefore recommended to use them as effective treatments in reducing the accumulation of harmful fat in the body and reducing weight.