الفهرس 
Stripping voltammetry (SV)
Investigated biologically active compoundsOnly 14 pages are availabe for public view
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Abstract
The field of electrochemical sensors has grown rapidly. Electrochemical sensors based on nanomaterials exhibit perfect electrochemical response toward drug oxidation and determination compared to the unmodified electrodes.
Nanomaterials {e.g., Ferrite NPs and graphene nanosheets (GR)} have been extensively used in improving the voltammetric responses for organic and inorganic materials due to their excellent adsorption ability and conductivity. Magnetite (Fe3O4), has attracted great attention for its high sensitivity and rapid response toward drug determination via the electrochemical method. The addition of another metal to magnetite can enhance its electrochemical and adsorptive properties than pure Fe oxides. It was reported that doping Mn or Cr in magnetite structure could provide a synergistic effect with Fe species for higher electrochemical reactivity.
To the best of our knowledge, there is no report on the electrochemical sensing and electrocatalytic property of MnxFe(3-x)O4 and CrxFe(3-x)O4 nanoparticles and graphen nanosheets for Ticagrelor hydrochloride (TIC.HCl) and Asenapine maleate (ASE.M) drugs detection.
So, the main aim of the present work is the investigation for the first time the electrochemical behavior of TIC.HCl and ASE.M drugs using cyclic voltammetric technique and their determination in their formulations and human blood at Mn and Cr ferrites NPs modified carbon paste electrodes, respectively using square-wave-adsorptive anodic stripping voltammetric (SW-AdASV) method .
On the other side, drug dissolution process plays a critical role in releasing any drug from its dosage form and making it available for subsequent gastrointestinal absorption. Thus, examination of the dissolution analysis of solid pharmaceutical dosage forms is a very essential test of product quality. It can be utilized as a sensitive method for differentiating between formulations of the same therapeutic drug. This dissolution process is relied not only on the drug physicochemical properties, but also on the dosage form formulations and their process of manufacturing. Therefore, continual dissolution analysis of marketed drug products is vital to ensure availability of quality medicines. HPLC method is highly sensitive of high resolution, no destruction of the components and the most suitable method for this propose.