الفهرس 
Cyclophosphamide
Antihypertensive and antioxidant activity of bananasOnly 14 pages are availabe for public view
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Abstract
Leaves and peels of Musa trees showed promising biomedical applications. Treatment with cyclophosphamide (CTX) for cancer patients is accompanied by severe side effects on multi-vital organs. The aim of this study is to evaluate the phytochemical compositions of Musa leaves and peels extracts. Also, to evaluate the ameliorative effects of MLE and MPE against hepato-renal dysfunction induced by CTX in mice. MLE and MPE were prepared. The total protein, lipids and carbohydrates contents were measured by spectrophotometric methods. The total phenolic, flavonoid, TAC, DPPH%, DPPH (IC50) and saponin contents were determined by quantitative methods. Furthermore, the phytochemical compounds of MLE and MPE were analyzed by gas chromatography mass spectrophotometry (GC-MS). Different concentrations of MLE and MPE (1-5g/kg) were used to determine the median lethal dose (LD50). Forty male albino mice (CD-1) were divided into four groups (n=10) as follows: Group1 (Gp1) was injected with 200 μl of sterile saline i.p. Gp2 was injected with CTX as a single dose (200 mg/kg) i.p. Gp3 and Gp4 were injected with CTX as in Gp2 then injected with MLE (175 mg/kg) or MPE (170 mg/kg) daily, respectively. 50% of mice in all groups were sacrificed after 15 days of treatments, and the rest of mice were sacrificed by day 30. Mice from each group were bled at days 3, 9, 15, 23 and 30 to determine the hematological, biochemical, and histological changes.