الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Psoriasis is one of the most prevalent chronic inflammatory skin diseases causing significant impairment of quality of life, at least to the same extent as other major
medical diseases.
Psoriasis is a chronic, inflammatory skin disease, characterized by raised,
red scaly plaques. This disease affect affects about 2-3% of the world-wide
population. Psoriasis is also associated with several comorbidities, suggesting that
the underlying pathogenesis of the disease is more than “skin deep”.
Psoriasis arises through chronic interactions between hyper-proliferative KCs
and infiltrating activated immune cells. Initially, psoriasis as considered solely to be
due to dysfunction of limiting KC proliferation. Infiltration of immune cells was
noticed, but not considered to be key in pathogenesis, but rather just a consequence
of the hyper-proliferating KCs.
Over the last 20 years, it has been continuously discussed whether psoriatic
skin lesions arise from a primary alteration in epidermal KCs or in dermal
immunocytes. Nowadays, it is believed that psoriasis is most likely a Th1/Th17
induced inflammatory disease.
LRG has been isolated from human serum in 1977, and is a plasma
glycoprotein of 312 amino acids in length and approximately 50 kda glycoprotein,
in which 20% of amino acid residues consist of leucine with a periodic pattern of
leucine rich repeat.
LRG is expressed by liver cells, neutrophils, endothelial cells and
macrophages. LRG expression is upregulated during early neutrophil
differentiation and is increased in response to acute phase mediatory such as IL-6,
TNF-α and IL-1β. Although LRG is thought to be associated with bacterial
infection, immunological diseases and several types of cancer, the precise function
of LRG still remained unknown. Recent study showed that serum levels of LRG
were significantly higher in patients with autoimmune diseases such as RA,
Crohn’s disease, Behçet disease and ulcerative colitis.
The current study was conducted on 30 psoriatic patients whose age ranged
from 20 to 53 years. The diagnosis of psoriasis was based on a thorough physical
examination and detailed history taking. The clinical grade of psoriasis was
assessed using the ‘‘classic’' PASI. Thirty healthy subjects who had no systemic or
dermatological diseases of matching age and sex served as control. Three ml blood
sample was taken for detection of serum levels of LRG using ELISA kits.
Our results revealed statistical significant difference in LRG levels between
control and patient groups with higher values in patient group. While there was no
statistically significant difference in LRG levels among patients as regards disease
severity degrees.
On the other hand there was no statistically significant in patient group
compared to control group as regards age, sex, smoking and Body Mass Index.
Also our resuts revealed that there was no statistically significant difference
in PASI severity in patient group as regards patient age, sex, family history, BMI,
smoking, duration(years) of psoriasis.
Also our study detected that there was no statistically significant difference
between PASI severity and LRG (pg/ml) in patient group. There was no
statistically significant difference in PASI score in patient group as regards patient
sex, family history and smoking.
There was no statistically significant correlation between PASI score and
any of age, duration (years), BMI or LRG(pg/ml) among cases.
Also the results revealed that there was statistically significant positive
correlation between LRG level and BMI which indicates that increasing in BMI
will be associated with increasing in LRG (pg/ml) level among cases.
On the other hand there was no statistically significant correlation between
LRG (pg/ml) level and any of age, duration or PASI among cases.
There was no statistically significant difference in LRG level in patient group
as regards patient sex, family history, smoking and PASI severity.
In conclusion, increased serum levels of LRG in psoriatic patients compared
to controls pay attention to their possible role in the pathogenesis of psoriasis. a
potential role for neutrophils in modulating the microenvironment through the
release of LRG1 from activated neutrophils. Also BMI has been supposed to be a
prog-nostic factor for the response to treatment in psoriasis.