الفهرس 
Neutrophil to lymphocyte, platelet to lymphocyte and eosinophil to lymphocyte ratios in systemic lupus
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Abstract
The development of hematological biomarkers in different autoimmune diseases has focused on assisting in diagnosis and monitoring disease activity. Some complete blood count (CBC) derived parameters have been used previously as markers for assessment of SLE.Objective: To look into the role of neutrophil to lymphocyte ratio (NLR), Eosinophil to lymphocyte ratio (ELR) and platelet to lymphocyte ratio (PLR) in systemic lupus erythematosus (SLE) and their relation to disease activity. Methods: In cross sectional case control analytical study including 164 subjects; 82 SLE patients and 82 healthy control subjects. All SLE patients were subjected to assessment of activity by systemic lupus erythematosus disease activity index (SLEDAI) score and assessment of CBC with differential. Outcome measures: to assess the NLR, PLR and ELR in SLE patients and their correlation with disease activity, so we can get better prognosis and detect the most effective treatment in this stage.Results: NLR and ELR were significantly increased in SLE patients compared to healthy control (HC) with P values (0.044 and 0.012) respectively, while there was no significant difference in PLR between SLE cases and HC with P value (0.16). both NLR and ELR showed a significant positive correlation to SLE activity assessed by SLEDAI score with P values (0.00 and 0.01 respectively) while, PLR showed no correlation to SLEDAI score P value (0.2). NLR, in particular, was higher in positive C- reactive protein (CRP) and positive anti-ds-DNA cases; positively correlated to erythrocyte sedimentation rate (ESR); and showed no significant relation with complement consumption or the presence of lupus nephritis