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Abstract Background: Patients with end stage renal disease undergone hemodialysis suffer from respiratory symptoms, uremic myopathy and protein catabolism which effect on quality of life and survival leading to reduction of functional capacity and respiratory muscle strength. Aim of this study : To find out the effect of intradialytic respiratory training on respiratory muscle strength and functional capacity in patients on hemodialysis. Methods: forty patients of both sexes (20 males and 20 females) with end stage renal disease on hemodialysis with mean age of 34.72 years were recruited from hemodialysis center of Fayoum University Hospital. The study lasted from November 2018 to December 2019. Patients received respiratory training with expand-a-lung device for12 successive weeks, 3 sessions/ week. The outcome measures were maximum inspiratory pressure (MIP), maximum expiratory pressure (MEP), forced vital capacity (FVC), forced expiratory volume in 1st second (FEV1), FEV1/FVC ratio, 6-minute walk test (6MWT) and fatigue severity scale (FSS) which were measured before and after the intervention. Results: There was a significant improvement in MIP, MEP, FEV1%, FVC%, 6MWT and FSS by 61.37%, 63.01%, 58.26%, 55.12%, 36.48% and 22.35% respectively (P<0.0001), while no significant difference was recorded regarding to FEV1/FVC% ratio (P=0.73). Conclusion: Based on these results, it can be concluded that respiratory muscles training can be an effective therapeutic technique to improve respiratory muscle strength and functional capacity in patients with end stage renal disease on hemodialysis |