الفهرس 
Study of programmed death ligand-1 (PD-l1) single nucleotide polymorphisms in non-hodghkin’s lymphoma
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Abstract
Background: The non-Hodgkin lymphomas (NHL) are a heterogeneous group of lymphoproliferative malignancies with differing patterns of behavior and responses to treatment. Several single nucleotide polymorphisms (SNPs) are considered to have significant impacts on susceptibility to the development of cancer. Several studies investigated the association between genetic polymorphisms of PD-L1 gene and the risk of various cancers.Objective:The aim of this study is to investigate the association of PDL1 rs4143815 and rs2890658 SNPs with the susceptibility of nonHodgkin’s lymphoma.Methods:The genotyping of PD-L1 gene was done using real-time polymerase chain reaction (real-time PCR) for 100 B-NHL patients and 100 healthy controls. Results: The study revealed that there was no significant association between PD-L1 rs4143815 and rs2890658 SNPs and risk of B-NHL. However, the relationship between the major alleles of rs4143815 (C>G) and rs2890658 (A>C) SNPs and adverse clinicopathological factors of BNHL patients revealed positive results.Conclusion: Our results provided the first evidence that PD-L1 rs4143815 (C>G) and rs2890658 (A>C) genetic polymorphism could not be predisposing markers in genetic susceptibility to B-NHL in a cohort of Egyptian population, at least in the studied population. However, these polymorphic sites could be candidates for predicting the adverse clinicopathological features of B-NHL and might be valuable for individual prognostic evaluations in Egyptian population.Although, validation by a larger prospective study from more diverse ethnic population is needed to confirm these findings