الفهرس 
Nanoparticles as drug delivery system for oral insulin
CONTENTSOnly 14 pages are availabe for public view
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Abstract
Insulin is a hormone secreted by the beta cells in the pancreas, which helps to maintain the blood glucose level stable. Since the discovery of insulin in 1921, it is of great importance in reducing complications of diabetic patients who depend on insulin. Insulin injections are painful and somewhat frightening for many patients. Because of these problems, novel approaches for insulin delivery are being explored, including oral, transdermal, nasal, rectal, pulmonary, uterine, and ocular delivery as well as subcutaneous implants. Oral insulin delivery would eliminate the pain caused by injection, psychological barriers associated with multiple daily injections such as needle anxiety and possible infections. Accordingly, the work in this thesis is divided into four parts. PART I: Pre-formulation study on insulin and certain biodegradable polymers Since drug-polymer binding may slow down the drug release and/or dissolution, it is essential to analyze drug-polymer interactions. The main objectives of this part were to investigate the possible interactions between water-soluble drug (insulin) and some biodegradable polymers viz. (sodium alginate, Chitosan and dextran sulphate).Drug-polymer blend films were prepared by solvent casting technique and analyzed using different techniques viz. differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction to characterize the nature of possible drug-polymer interactions then the drug release from the blend films was studied at 37OC under agitation. The results indicated that there were minor interaction between insulin and polymers