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Abstract The Congo River Basin is an important global freshwater resource. The hydrological Regime of the region is vulnerable to climatic variations, especially precipitation and temperature. In our study, we modelled the impact of climate change in water resources in the Congo River Basin. The MIKE Zero (MIKEHYDRO) using Rainfall-Runoff MIKE 11 NAM model was used for calibration and validation and for the future projection of changes in the hydrological regime of the Congo River Basin based on Representative Concentration Pathways Scenarios (RCP 4.5 and RCP 8.5) from the Coordinated Regional Downscaling Experimented (CORDEX AFRICA) regional Climate Model (RCMs) outputs. It was concluded that the climate changes affect the discharge of Congo river significantly during dry and wet season. The average increase in the runoff discharge from tributaries of Congo River ranges from 21% (intermediate future) to 117% (near future), also the average decrease of runoff discharge from tributaries in Congo river ranges from 17% to about 60% at the intermediate future zone |