الفهرس 
Title : Subconjunctival versus combined subconjunctival and subscleral Mitomycin C in pediatric trabeculectomy: A Randomized Clinical Study.
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Abstract
Introduction: To compare the safety and efficacy of trabeculectomy augmented by subconjunctival application of Mitomycin C (MMC) versus combined subconjunctival and subscleral flap MMC application in primary congenital glaucoma (PCG). Methods: This prospective, randomized, interventional study included children aged {u2264} 6 years, requiring a trabeculectomy for PCG. Fifty eyes were randomly assigned to undergo trabeculectomy with subconjunctival MMC application (group A, 25 eyes), or trabeculectomy with combined subconjunctival and subscleral flap MMC application (group B, 25 eyes). Success was defined as achieving an intraocular pressure (IOP) {u2264} 18 mmHg at 12 months, without medications (complete success) or with antiglaucoma medications (qualified success). Postoperative results were compared at 1,3,6,9,12 months and the final follow-up. The main outcome measures were: IOP, number of glaucoma medications, surgical success, postoperative interventions and complications in both groups Results: At 12 months, the percent IOP reduction for group A was 45.6% and for group B 46.8%. Total success was achieved in 68% and 72% of eyes in groups A and B, respectively. Failure tended to occur earlier in group B. Kaplan-Meier analysis for complete success showed cumulative probability of survival of 53% for group A and 40% for group B (P-value=0.38). Needling was more successful in group B with 60 % total success compared to 33.3% in group A (P-value=0.39)