الفهرس 
Title : The Value of Adding Tranexamic Acid to Fractional CO2 Laser in the Treatment of Hyperpigmented Burn Scars. Evaluation by High Intensity Skin Ultrasound
AbstractOnly 14 pages are availabe for public view
 |  | from | 131 |  |  |
| | | from | 131 | | |
Abstract
Background:Treatment of post burn hyperpigmented scars still an aesthetic challenge. Fractional CO2 proved efficacy in this regard. Tranexamic acid is popular for its depigmenting effect for melasma and post inflammatory hyperpigmentation. In vitro studies showed possible contribution of TXA in collagen remodeling. Aim of work: To assess whether the use of TXA will enhance the effect of fractional CO2 laser in the treatment of hyperpigmented post burn scars. Material and Methods: Twenty patients of both sex with two separate post burn scars or large scars divided into two areas (A, B), were randomly assigned to treatment with fractional co2 laser and combined fractional CO2 laser and TXA dermal injection. The improvement was assessed clinically by Vancouver scar scale(VSS) and objectively through evaluation of scar thickness by (HFSU). Spectrophotometer was also used for assessment of erythema and pigmentation. Results: Combined fractional CO2 and TXA injection showed significantly better clinical improvement than did fractional CO2 laser alone, indicated by VSS score (P value <0.001), significantly less dermal thickness assessed by HFSU (P value <0.001). As well as significantly better improvement in erythema and pigmentation assessed by spectrophotometer. Conclusion:Our results proved that the adjunctive use of TXA with fractional CO2 laser showed synergistic effect in treatment of postburn hyperpigmented scars, with significant improvement in all scar criteria