الفهرس 
Title : Assoclation between blood coagulability and migraine
AbstractOnly 14 pages are availabe for public view
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Abstract
Background: An association between migraine and stroke has been suggested for a longer period, although conclusive evidence has not been reported. Several explanations have been proposed for the association of vascular diseases and migraine especially migraine with aura, including some theories about hypercoagulability as a link between migraine and ischemic stroke.Objective: This study aimed to assess hypercoagulability in patients with migraine by evaluating serum levels of protein C, protein S and antithromibin III, and to examine correlation of these parameters with age and clinical characteristics of migraine. Subjects and Methods: Thirty-five migraine patients and thirty-five matched normal control subjects participated in this study. Patients were subjected to complete clinical assessment. Measurement of serum levels of protein C, protein S or anti-thrombin III, and non-contrast Magnetic Resonance Imaging (MRI) of the brain were done for migraine patients and control subjects.Results: Mean serum levels of protein S and anti-thrombin III were significantly lower in migraine patients compared to normal subjects. Migraine patients showed abnormal MRI findings in the form of white matter hyper-intense lesions (WMHLs) and ischemic foci compared to healthy controls. No statistically significant difference was detected between patients subgroups (migraine with aura versus migraine without aura) regarding mean serum levels of protein C, protein S, and anti-thrombin III or brain MRI findings. A significant negative correlation was detected between serum protein C level and intensity of migraine headache. Also, a significant correlation was found between deficient serum protein S and abnormal findings in brain MRI. Serum protein C deficiency is an independent predictor for migraine intensity grade