الفهرس 
Striae Distensae
Enhancing collagen productionOnly 14 pages are availabe for public view
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Abstract
Summary
The SD, often referred to as stretch marks, are common linear lesions
seen in individuals of all ages. Predominantly seen in females, they are often
associated with various physiologic states, including puberty, pregnancy,
weight gain or weight loss, obesity, and disorders related to hypercortisolism.
Early lesions may be mildly pruritic and often appear pink to red, hence, the
term striae rubra. Lesions may gradually lighten and become atrophic, which
are then referred to as striae alba. Although lesions occasionally fade with
time, SD are typically considered to be permanent.
The pathogenesis of SD has yet to be fully elucidated. However,
current theories suggested that SD result from stretching of the skin, which
leads to aberration of dermal collagen and elastic fibers. Genetic factors and
hormonal changes associated with puberty or pregnancy are also thought to
play a role. Various treatment modalities have been utilized with varying
degrees of success. A significant need remains for a safe and effective
treatment option for SD.
The amnion is the innermost layer of fetal membranes, which form a
sac filled with the amniotic fluid, thus surrounding and protecting the embryo,
the amniotic epithelial cells produce numerous cytokines and factors known
to promote cell proliferation and differentiation.
The MN is a simple office procedure that involves creating thousands
of micro clefts through the epidermis into the papillary dermis, so it enhances
penetration of growth factors.
The aim of the study was to assess the efficacy and safety of irradiated
amniotic collagen matrix with MN in treatment of Stretch marks.
This prospective study was carried out on (20) patients presenting with
Striae. All participants were subjected to full history taking, general and