الفهرس 
Management strategy for surgical intervention in patients with nodular thyroid disease
Table of contentsOnly 14 pages are availabe for public view
 |  | from | 112 |  |  |
| | | from | 112 | | |
Abstract
Background: Thyroid nodules are highly prevalent and with greater use of more sensitive imaging modalities, there are even higher proportion of incidentally discovered thyroid nodules. The ideal approach for diagnosis and clinical management of thyroid nodules is controversial, thus an evidence-based and systematic approach is needed to lead to dependability regarding their management in order to avoid unnecessary surgery.Material and Method: All publications regarding the management policy of simple nodular thyroid disease were reviewed in the following search engines [PubMed, Embase, Ovid, Scopus, Cochrane library and Science direct]. The full articles of the selected abstracts were included in the study after assessment of the study power as determined by JADAD scale for prospective randomized study. Meta-analysis was performed in agreement with the preferred reporting items for systematic reviews and meta-analyses (PRISMA) statement using RevMan 5 software and comprehensive meta-analysis version 2.0. Results: Ten studies were included in our meta-analysis, involving a total of 1734 patients. No significant differences were found between total thyroidectomy and Dunhill operation regarding the post-operative complications.No significant differences were found between truncal and terminal ligation of inferior thyroid artery regarding the postoperative parathyroid functions. Significantly lower intraoperative blood loss (mean difference = 0.61; 95% CI [0.47, 0.75]; P <0.00001) and shorter operative time (mean difference = 0.99; 95% CI [0.85, 1.14]; P <0.00001) are associated with ligasure than tying and knotting technique, but they were comparable regarding post-operative complications